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Pharmaceutical makers, academics come together mental illness Posted: 11 Nov 2010 05:35 AM PST Nine large pharmaceutical company decided to put information about drug trials at academic institutions in an attempt to explore treatment increased the chances of developing new drugs for psychiatric disorders such as schizophrenia. The collaboration with Pfizer, AstraZeneca, Eli Lilly and Roche among others, the data from 67 tests over 11 approved drugs represent the largest database of clinical data in psychiatric research, but to gather the leaders of the project. “We have learned a lot of brain research in the last 30 years … and it is expected that this knowledge was quickly and automatically translate new drugs,” says Kapur Shitij London Institute of Psychiatry at King’s College, the project director named new methods that will lead to new drugs for depression and schizophrenia or NEWMEDS. “But he is here because the record was a bit disappointing. Kapur said that the goal NEWMEDS for academic researchers and pharmaceutical companies learn from the past and find ways to speed up and simplify the process of obtaining drug candidates through clinical trials market. “We hope that this move inversely to help the drought of new drugs in psychiatry,” he said. One obstacle was the development of competition between rival companies, he said, a limited exchange of knowledge between different departments of the Academy. Data Sharing NEWMEDS statement pointed to three problem areas in drug discovery for psychiatric disorders, including lack of animal models, careful experiments show the lack of tools and tests in healthy volunteers that the first signs that do the drugs can and focus on clinical research methods, the almost remained unchanged for 50 years. Pharmaceutical companies are not worried about exposure developing experimental drugs, but we share the information about drugs that have already received approval. Eli Lilly, for example, sharing of data from experiments of its schizophrenia drug Risperdal, or risperidone, while AstraZeneca will open the archive to Seroquel or quetiapine. “For 50 years we have rehearsed in the same way – with a standard placebo or active control for four to six weeks and using statistical methods,” said Jonathan Rabinowitz, Bar Ilan University in Israel, the data analysis NEWMEDS schizophrenia project out. “By creating this series of large amounts of data … we can determine whether the evidence can be smaller, faster, and patients exposed to new drugs.” Academic institutions that deal with the Swedish Karolinska Institute, Cambridge, UK University of Manchester, the Spanish National Research Council of the German National Institute of Mental Health. Other pharmaceutical companies are units of Janssen Pharmaceutica Johnson & Johnson, Lundbeck, Novartis, Orion, serving private. Nine major pharmaceutical companies have agreed to pool data on drug trials with academic institutions in an effort to improve ways of developing of new medicines to treat psychiatric disorders such as schizophrenia.The collaboration, which involves Pfizer, AstraZeneca, Eli Lilly and Roche among others, will bring together data on 67 trials on 11 licensed drugs and will make up the largest database of clinical trial data in psychiatric research, according to the project’s leaders. “We have learnt a lot of brain science in the last 30 years … and the expectation is that this knowledge would automatically and quickly translate into new medications,” said Shitij Kapur of the Institute of Psychiatry at King’s College London, a leaders of the project called Novel Methods leading to New Medications in Depression and Schizophrenia, or NEWMEDS. “But that is where the track record has been a little disappointing.” Kapur said the aim of NEWMEDS was for scientific researchers and drug companies to learn from past experience and devise ways to speed up and simplify the process of getting a potential drug candidate through clinical trials and onto the market. “Hopefully, this will be one step that will help reverse the drought of new medications in psychiatry,” he said. One barrier to development has been competition between rival companies, he said, while another has been the limited exchange of science across the industry-academic divide. SHARING DATA In a statement NEWMEDS pointed to three bottlenecks in drug discovery for psychiatric disorders, including a lack of accurate animal models for experimentation, a lack of tools and tests in healthy volunteers to give early indications of whether drugs might work, and reliance on clinical trial methodology that has remained virtually unchanged for 50 years. The drug firms involved will not disclose information about experimental drugs they are developing but will share data on drugs that have already won approval to be marketed. Eli Lilly, for example, will share data from trials of its schizophrenia drug Risperdal, or risperidone, while AstraZeneca will open up its archives on Seroquel, or quetiapine. “For 50 years we have been doing trials the same way — with a standard placebo or active control, for four to six weeks and using the same statistical approaches,” said Jonathan Rabinowitz of Bar Ilan University in Israel, who will lead analysis of the schizophrenia data for the NEWMEDS project. “By bringing together this large dataset … we will be able to identify if trials could be smaller, faster and can decrease exposure of patients to experimental medications.” Academic institutions involved include Sweden’s Karolinska Institute, Britain’s Cambridge and Manchester universities, the Spanish National Research Council and Germany’s Central Institute of Mental Health. The other drugmakers are Johnson & Johnson’s unit Janssen Pharmaceutica, Lundbeck, Novartis, Orion and privately-owned Servier. |
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